Pyrargyrite is noted from many of the classic silver-producing localities in Western Europe and Latin America. Gemany contains several classic localities in Saxony, where outstanding Pyrargyrite was found in sharp, well-formed crystals. Localities there include the St Andreasberg District, Harz Mountains; the Freiberg District, Erzgebirge; and the Schlema and Schneeberg Districts, Erzgebirge.
Other classic European Pyrargyrite localities include Jáchymov, Krušné Hory Mts, Bohemia, Czech Republic; Příbram, Bohemia, Czech Republic; and Hiendelaencina, Guadalajara, Spain.
Important South American localities for Pyrargyrite are the Uchucchacua Mine, Oyon, Lima Department, Peru; the San Genaro Mine, Castrovirreyna, Huancavelica Department, Peru; Porco and Colquechaca, Potosí Department, Bolivia; and Chañarcillo, Copiapó Province, Atacama Desert, Chile.
In Mexico, lustrous, complex crystals have come from Fresnillo, Zacatecas; and large crystals clusters from the San Juan de Rayas Mine, Guanajuato. Pyrargyrite is very rare in U.S., with few localities producing any specimens of note, though small microcrystals occur at the Advance Mine, Colorado Hill, Alpine Co., California.